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H5N1 avian influenza virus without 80-84 amino acid deletion at the NS1 protein hijacks the innate immune system of dendritic cells for an enhanced mammalian pathogenicity.
Chen S, Miao X, Huangfu D, Zhao X, Zhang M, Qin T, Peng D, Liu X. Chen S, et al. Transbound Emerg Dis. 2021 Jul;68(4):2401-2413. doi: 10.1111/tbed.13904. Epub 2020 Nov 17. Transbound Emerg Dis. 2021. PMID: 33124785
NS gene is generally considered to be related to the virulence of highly pathogenic avian influenza virus (AIV). In recent years, the strains with five amino acids added to the 80-84 positions of the NS1 protein have become prevalent in H5N1 subtype AIVs isol …
NS gene is generally considered to be related to the virulence of highly pathogenic avian influenza virus (AIV). In recent years, the …
Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity.
Nogales A, Villamayor L, Utrilla-Trigo S, Ortego J, Martinez-Sobrido L, DeDiego ML. Nogales A, et al. Viruses. 2021 Sep 3;13(9):1760. doi: 10.3390/v13091760. Viruses. 2021. PMID: 34578340 Free PMC article.
To study the determinants of IAV pathogenicity and their functional co-evolution, we evaluated amino acid differences in the PA-X and NS1 proteins of early (1996-1997) and more recent (since 2016) H5N1 IAV. H5N1 IAV have zoonotic and pandemic potential and re …
To study the determinants of IAV pathogenicity and their functional co-evolution, we evaluated amino acid differences in the PA-X and NS1 …
Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells.
Lam WY, Tang JW, Yeung AC, Chiu LC, Sung JJ, Chan PK. Lam WY, et al. J Virol. 2008 Mar;82(6):2741-51. doi: 10.1128/JVI.01712-07. Epub 2008 Jan 16. J Virol. 2008. PMID: 18199656 Free PMC article.
Avian H5N1 influenza virus causes a remarkably severe disease in humans, with an overall case fatality rate of greater than 50%. ...Furthermore, 24 h posttransfection, an increase in Fas ligand mRNA expression of about 5.6-fold was detected in cells transfected with …
Avian H5N1 influenza virus causes a remarkably severe disease in humans, with an overall case fatality rate of greater than 50 …
Cross-clade protective immune responses of NS1-truncated live attenuated H5N1 avian influenza vaccines.
Shi S, Chen S, Han W, Wu B, Zhang X, Tang Y, Wang X, Zhu Y, Peng D, Liu X. Shi S, et al. Vaccine. 2016 Jan 12;34(3):350-7. doi: 10.1016/j.vaccine.2015.11.045. Epub 2015 Nov 27. Vaccine. 2016. PMID: 26638027
BACKGROUND: H5N1 highly pathogenic avian influenza (HPAI) has raised global concern for causing huge economic losses in poultry industry, and an effective vaccine against HPAI is highly desirable. ...METHODS: A series of H5N1 avian influenza virus reas …
BACKGROUND: H5N1 highly pathogenic avian influenza (HPAI) has raised global concern for causing huge economic losses in poultr …
Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein.
Zhu CY, Zheng FL, She XS, Zhao D, Gu Y, Duan YT, Chang AK, Liu HS. Zhu CY, et al. Virus Genes. 2015 Apr;50(2):238-44. doi: 10.1007/s11262-015-1166-0. Epub 2015 Feb 3. Virus Genes. 2015. PMID: 25645906
Non-structural protein 1 (NS1) is an important virulence factor encoded by influenza A virus. ...To investigate the exact region of NS1 that interacts with NOLC1, we used only the effector domain of NS1 and constructed various mutants having different deletio …
Non-structural protein 1 (NS1) is an important virulence factor encoded by influenza A virus. ...To investigate the exact region of …
Synergistic effect of the PDZ and p85beta-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus.
Fan S, Macken CA, Li C, Ozawa M, Goto H, Iswahyudi NF, Nidom CA, Chen H, Neumann G, Kawaoka Y. Fan S, et al. J Virol. 2013 May;87(9):4861-71. doi: 10.1128/JVI.02608-12. Epub 2013 Feb 13. J Virol. 2013. PMID: 23408626 Free PMC article.
Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype continue to evolve through reassortment and mutations. ...Here, we show that an HPAI H5N1 virus (A/duck/Hunan/69/2004) encoding NS1-ESKV and NS1-138Y was confined to the respir …
Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype continue to evolve through reassortment and mutations. .. …
A 20-amino-acid deletion in the neuraminidase stalk and a five-amino-acid deletion in the NS1 protein both contribute to the pathogenicity of H5N1 avian influenza viruses in mallard ducks.
Li Y, Chen S, Zhang X, Fu Q, Zhang Z, Shi S, Zhu Y, Gu M, Peng D, Liu X. Li Y, et al. PLoS One. 2014 Apr 17;9(4):e95539. doi: 10.1371/journal.pone.0095539. eCollection 2014. PLoS One. 2014. PMID: 24743258 Free PMC article.
Since 2003, H5N1-subtype avian influenza viruses (AIVs) with both a deletion of 20 amino acids in the stalk of the neuraminidase (NA) glycoprotein (A-) and a deletion of five amino acids at positions 80 to 84 in the non-structural protein NS1 (S-) have become …
Since 2003, H5N1-subtype avian influenza viruses (AIVs) with both a deletion of 20 amino acids in the stalk of the neuraminida …
Exosomes from H5N1 avian influenza virus-infected chickens regulate antiviral immune responses of chicken immune cells.
Hong Y, Truong AD, Vu TH, Lee S, Heo J, Kang S, Lillehoj HS, Hong YH. Hong Y, et al. Dev Comp Immunol. 2022 May;130:104368. doi: 10.1016/j.dci.2022.104368. Epub 2022 Jan 29. Dev Comp Immunol. 2022. PMID: 35104460
Exosomes (membrane-derived vesicles) enable intracellular communication by delivering lipids, proteins, DNA, and RNA from one cell to another. Highly pathogenic avian influenza virus (HPAIV) H5N1 causes considerable economic loss in the poultry industry and poses a …
Exosomes (membrane-derived vesicles) enable intracellular communication by delivering lipids, proteins, DNA, and RNA from one cell to anothe …
Proteomic analysis of chicken embryo fibroblast cells infected with recombinant H5N1 avian influenza viruses with and without NS1 eIF4GI binding domain.
Guo K, Lin X, Li Y, Qian W, Zou Z, Chen H, Zhou H, Jin M. Guo K, et al. Oncotarget. 2017 Dec 22;9(9):8350-8367. doi: 10.18632/oncotarget.23615. eCollection 2018 Feb 2. Oncotarget. 2017. PMID: 29492200 Free PMC article.
A recombinant H5N1 virus lacking the eIF4GI-binding domain of NS1 (rNS1-SD30) exhibits significantly lower pathogenicity than H5N1 virus with an intact eIF4GI-binding domain (rNS1-wt). ...These findings highlight the role of NS1 eIF4GI binding domain i …
A recombinant H5N1 virus lacking the eIF4GI-binding domain of NS1 (rNS1-SD30) exhibits significantly lower pathogenicity than …
139 results